Yes.

GSAP itself is pure JavaScript and should work in virtually ALL browsers. GSAP wasn’t intended to solve all browser incompatibilities, but it does implement wizardry for critical features like opacity, transforms (rotation, scaleX, scaleY, skewX, skewY, x, and y), and transformOrigin so those should work in all major browsers even back to IE6. Firefox doesn’t support backgroundPositionX or backgroundPositionY, so those specific properties won’t work but backgroundPosition will for virtually all browsers. There is NOT a predetermined list of css properties that you can tween – the platform will attempt to tween ANY property you pass in. If it is numeric, it will tween it. If it isn’t numeric and it isn’t a recognized special property, CSSPlugin will just set the property to the value you provide (without tweening it). So, for example, if you try to tween to display:"inline", that isn’t a tweenable property but it will still be set accordingly during the tween, so feel free to use that to your advantage.

CSS3 transitions have some significant limitations that make them unworkable for a serious animation platform. They don’t provide precise controls over the timing or easing. They’re great for simple effects but the GreenSock Animation Platform delivers extremely precise rendering, so you can do things like pause() and reverse() an animation anytime or skip to a specific time and play from there, etc. Try creating a CSS3 transition that uses an elastic.out or slow motion ease and then jump to 0.72494-seconds into a 2-second transition and pause() only to resume() later. It’s impossible from what I understand. So no, the platform doesn’t make use of CSS3 transitions. However, it is highly optimized for performance. See the detailed cage match where GSAP battles CSS3 transitions where there’s a detailed comparison in several categories.